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204 Similarly, administration of the PRMT5 inhibitor PJ-68 in a CML mouse model with high expression of PRMT5 LSCs could deplete DVL3, thereby inhibiting Wnt/-catenin signaling and significantly prolonging the survival time of a retroviral BCR-ABL-driven CML mouse model

Acikel, M., Buyukokuroglu, M.E., Erdogan, F., Aksoy, H., Bozkurt, E

Serious allergic reactions such as hives, swollen lips or tongue, a tight throat, and a wheezy chest

excessive melanin leads to hyperpigmentation, dark spots, and uneven skin tone

However, many cancer subtypes lack hormone/growth factor sensitive cells (e.g., high aggressive basal-like cancers)

This ensures that the hormone therapy works